Publications – Laboratory of Molecular Materials at Linköping

The Molecular Basis for Inhibition of Stemlike Cancer Cells by

Product correctly added to cart. × 2014-09-30 Liposome and Lipid Nanoparticle Synthesis. The ability to produce monodisperse liposomes and lipid nanoparticles with narrow size distribution and acutely control the reproducibility is crucial for the scientific and pharmaceutical communities. 2021-02-05 Liposomes and lipid nanoparticles (LNPs) Accurate Liposome and LNP quantification. Nanoparticle analysis using resistive pulse sensing avoids many of the difficulties associated with DLS and optical tracking. Spectradyne is the only company providing microfluidic particle size analysis.

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Drug-lipid complexes are formed by mixing a drug with lipids in such a way that liposomes are not created. The. CMC, pharmacokinetics, and bioavailability  by PG Microfluidic Mixing System · A liposome is a spherical vesicle with at least one lipid bilayer. · ​ · Liposomes are composite structures, consisting of  Nov 24, 2020 Solvent-free production methods for liposomes & lipid nanoparticles: Dr Yvonne Perrie, Professor, Strathclyde Institute of Pharmacy  Jul 23, 2019 It was the aim of the present study to design and optimize a nanoparticle based on liposomes combined with derivatives of Myrcludex B to  Conventional liposomes are known to interact with certain serum factors, including For LNP-formulated RNAi therapeutics, the lipid vehicle and the siRNA  Jan 30, 2020 In liposome and lipid nanoparticle (LNP) drug-delivery applications, particle size is an important quality attribute (CQA) that can impact  We conclude that both exosomes and lipid nanoparticle are suitable options as to previous developments of other lipid-based vesicles like liposomes and  Mar 1, 2013 SLNs combine all the advantages of polymeric nanoparticles, fat emulsions and liposomes. Fig 2. FIG. 2: A DIAGRAMMATIC REPRESENTATION  Mar 19, 2019 In order to utilize the unique attributes of liposomes and polymeric NPs that led to their initial clinical success, but overcome limitations like  Jan 16, 2020 2.4 Production of lipid nanoparticles containing siRNA and lipophilic taxane Extrusion-Free Method for Efficient Liposomal Encapsulation of  Mar 20, 2020 controllable production of liposomes and lipid nanoparticles (LNP) with two different chip geometries 1) hydro-dynamic flow focussing,  Nov 28, 2017 Lipid nanoparticles (LNPs) or liposomes are the most widely used drug Here, we demonstrated the effect of lipid concentration and mixing  In general, solid lipid nanoparticles have a higher entrapment efficiency for hydrophobic drugs in the core compared with conventional liposomes, and they are  Apr 13, 2020 We've seen a tremendous number of fly-by-night brands of liposomal We think that it's important to understand what is “liposomal” and Nanoparticle toxicity by the gastrointestinal route: evidence and knowl A liposome is a spherical vesicle having at least one lipid bilayer. The liposome can be used as a vehicle for administration of nutrients and pharmaceutical  You've probably been hearing more and more about liposomes.

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2014), and PTX–LDE, a lipid core nanoparticle with encapsulated paclitaxel that binds to low-density lipoprotein receptors of cancer cells and concentrates in the tumor tissues (Graziani et al. 2017). Liposomes and lipid nanoparticles serve as versatile drug delivery systems, offering control over composition, structure, and morphology, where these properties can be tailored to each specific pharmaceutical application. 2020-07-01 · Reproducible lipid nanoparticle manufacturing: Limited process control leads to lipid nanoparticle heterogeneity: Controlled manufacturing conditions result in homogeneous lipid nanoparticle formulations: Loading nanoparticles with nucleic acids are inefficient: High nucleic acid loading efficiency in a one-step formulation process 2017-11-28 · Lipid nanoparticles (LNPs) or liposomes are the most widely used drug carriers for nanomedicines.

Lipid nanoparticles under shear stress require novel flow

2014 Dec;10(12):3647-57. doi: 10.1166/jbn.2014.1874. Liposomes versus Lipid Nanoparticles: Comparative Study of Lipid-Based Systems as Oryzalin Carriers for the Treatment of Leishmaniasis December 2014 Journal of Biomedical Nanotechnology 10(12) Lipid nanoparticles (LNPs) and liposomes are variations of lipid-based drug carriers differing in their internal structure.

2020-08-04 There are two main differences between liposomes and lipid nanoparticles. 1. Liposomes are spherical vesicles formed mainly by phospholipids and other physiologic lipids, while lipid nanoparticles are solid particles at room and body temperature, consisting of solid lipids (SLN) or a mixture of a solid lipid and a liquid lipid (NLC). 2014-12-01 Liposomes versus lipid nanoparticles: comparative study of lipid-based systems as oryzalin carriers for the treatment of leishmaniasis. Main-stay in treatment of leishmaniasis relies on chemotherapy but none of the current drugs combines high activity and low toxicity at affordable costs. Dinitroanilines are a new class of drugs with proved in Lipid nanoparticles, especially liposomes and lipid/nucleic acid complexed nanoparticles have shown great success in the pharmaceutical industry. Their success is attributed to stable drug loading, extended pharmacokinetics, reduced off-target side effects, and enhanced delivery efficiency to disease targets with formidable blood-brain or plasma membrane barriers.
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Liposomes are spherical vesicles characterized by a bilayer of lipids with an internal  Dec 16, 2016 Owing to outer lipid bilayer, our liposome/Au nanoparticle shows better Hybrids of liposomes and metal nanoparticles have been prepared  Jul 20, 2017 Of the nanocarriers, lipid-based and polymeric nanoparticles are the most widely used. Lipid-based systems like niosomes and liposomes are  Nanoparticles, and liposomes in particular, have been used for drug delivery in Nanoparticles comprised of polymers or lipids can be used to encapsulate  Dec 1, 2005 The development of STEALTH liposomes was based on the discovery that incorporation of polyethylene glycol (PEG)-lipids into liposomes yields  Mar 1, 2013 SLNs combine all the advantages of polymeric nanoparticles, fat emulsions and liposomes.

Liposomes and lipid nanoparticles serve as versatile drug delivery systems, offering control over composition, structure, and morphology, where these properties can be tailored to each specific pharmaceutical application. 2020-07-01 · Reproducible lipid nanoparticle manufacturing: Limited process control leads to lipid nanoparticle heterogeneity: Controlled manufacturing conditions result in homogeneous lipid nanoparticle formulations: Loading nanoparticles with nucleic acids are inefficient: High nucleic acid loading efficiency in a one-step formulation process 2017-11-28 · Lipid nanoparticles (LNPs) or liposomes are the most widely used drug carriers for nanomedicines. The size of LNPs is one of the essential factors affecting drug delivery efficiency and therapeutic efficiency.
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Lipid nanoparticles under shear stress require novel flow

Influenza virus adjuvant and lipid nanoparticles provides broadly protective immunity against influenza or liposome nanoparticles, which were administered intranasally. A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection.

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LNAs are liposome structures in which nanoparticles (NPs) are encapsulated in the aqueous core, embedded in the lipid bilayer, or coupled to the bilayer surface . by PG Microfluidic Mixing System · A liposome is a spherical vesicle with at least one lipid bilayer. · ​ · Liposomes are composite structures, consisting of  In general, solid lipid nanoparticles have a higher entrapment efficiency for hydrophobic drugs in the core compared with conventional liposomes, and they are  Lipid based nanocarrier systems. Solid lipid nanoparticles, liposomes, polymeric nanoparticles and non-structured lipid carriers are often used as delivery and  Aug 28, 2020 Lipid nanoparticles (LNPs) have received significant attention in recent Figure 1: A liposome encapsulating an aqueous core and a bilayer  Liposomes and lipid nanoparticles coated with hydrophilic polymers such as  SLN were developed in the 1990s as an alternative carrier system to the existing traditional carriers, such as emulsions, liposomes and polymeric nanoparticles. Mar 19, 2019 Doxil and Myocet, two leading doxorubicin liposomes, received Food and Drug Administration (FDA) approval in 1995 and 1999, respectively,  Jan 16, 2020 2.4 Production of lipid nanoparticles containing siRNA and lipophilic taxane Extrusion-Free Method for Efficient Liposomal Encapsulation of  Successful drug delivery with liposomes.

Geneva: Springer International Publishing; 2015. Garanti T, Stasik A, Burrow AJ, Alhnan MA, Wan KW. Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid … Lipid Nanoparticles in solid state: • derived from o/w emulsions • simply replacing the liquid lipid (= oil) by a solid lipid • (i.e. solid at body temp.) Definitions PharmaSol GmbH No. 10 No. 10 SLN – Solid Lipid Nanoparticles • produced from 1 solid lipid NLC – Nanostructured Lipid Carriers: • produced from blend of solid and liquid lipids Lipid nanoparticles (LNPs) and liposomes are variations of lipid-based drug carriers differing in their internal structure.